Infertility and Acupuncture FAQ 5

Infertility and Acupuncture References    

Updated November 2014 by Tim H. Tanaka, Ph.D., R.AC., R.TCMP


  1.  Chang R, Chung PH, Rosenwaks Z. Role of acupuncture in the treatment of female infertility. Fertil Steril. Dec 2002;78(6):1149-1153.
  2. Emmons S, Patton P. Acupuncture treatment for infertile women undergoing intracytoplasmic sperm injection. Medical Acupuncture: A Journal for Physicians by Physicians. 2000;12(2).
  3. Stener-Victorin E, Waldenstrom U, Andersson SA, Wikland M. Reduction of blood flow impedance in the uterine arteries of infertile women with electro-acupuncture. Hum Reprod. Jun 1996;11(6):1314-1317.
  4. Ho M, Huang LC, Chang YY, et al. Electroacupuncture reduces uterine artery blood flow impedance in infertile women. Taiwanese journal of obstetrics & gynecology. Jun 2009;48(2):148-151.
  5. Kobayashi M, Takahashi J, Suzuki H. Nanchisei funinshou ni taisuru shinkyu chiryou no kentou 4 (Acupuncture treatment on intractable infertility 4th report: Summary of 57 cases of insufficient endometrium lining treated with ART and acupuncture – Follow- up). Journal of the Japan Society of Acupuncture and Moxibustion. 2003;53(3):380.
  6. Suzuki H, Takahashi J, Kobayashi M, Ochi M. Nanchisei funinshou ni taisuru shinkyu chiryou no kentou 1 (Acupuncture treatment on intractable infertility – 1st report: Summary of 57 cases of insufficient endometrium lining treated with ART and acupuncture). Journal of the Japan Society of Acupuncture and Moxibustion. 2002;52(3):309.
  7. Fu H, He Y, Gao Y, Man Y, Liu W, Hao H. Acupuncture on the Endometrial Morphology, the Serum Estradiol and Progesterone Levels, and the Expression of Endometrial Leukaemia-inhibitor Factor and Osteopontin in Rats. Evid Based Complement Alternat Med. 2011;2011:606514.
  8. Shuai Z, Lian F, Li P, Yang W. Effect of transcutaneous electrical acupuncture point stimulation on endometrial receptivity in women undergoing frozen-thawed embryo transfer: a single-blind prospective randomised controlled trial. Acupunct Med. Oct 10 2014.
  9. Gerhard I, Postneek F. Auricular acupuncture in the treatment of female infertility. Gynecol Endocrinol. Sep 1992;6(3):171-181.
  10. Stener-Victorin E, Waldenstrom U, Tagnfors U, Lundeberg T, Lindstedt G, Janson PO. Effects of electro-acupuncture on anovulation in women with polycystic ovary syndrome. Acta Obstet Gynecol Scand. Mar 2000;79(3):180-188.
  11. Johansson J, Redman L, Veldhuis PP, et al. Acupuncture for ovulation induction in polycystic ovary syndrome: a randomized controlled trial. American journal of physiology. Endocrinology and metabolism. May 1 2013;304(9):E934-943.
  12. Rubinstein M, Marazzi A, Polak de Fried E. Low-dose aspirin treatment improves ovarian responsiveness, uterine and ovarian blood flow velocity, implantation, and pregnancy rates in patients undergoing in vitro fertilization: a prospective, randomized, double-blind placebo-controlled assay. Fertil Steril. May 1999;71(5):825-829.
  13. Sher G, Fisch JD. Vaginal sildenafil (Viagra): a preliminary report of a novel method to improve uterine artery blood flow and endometrial development in patients undergoing IVF. Hum Reprod. Apr 2000;15(4):806-809.
  14. Chen BY, Yu J. Relationship between blood radioimmunoreactive beta-endorphin and hand skin temperature during the electro-acupuncture induction of ovulation. Acupuncture & electro-therapeutics research. 1991;16(1-2):1-5.
  15. Mo X, Li D, Pu Y, Xi G, Le X, Fu Z. Clinical studies on the mechanism for acupuncture stimulation of ovulation. J Tradit Chin Med. Jun 1993;13(2):115-119.
  16. Ng EH, So WS, Gao J, Wong YY, Ho PC. The role of acupuncture in the management of subfertility. Fertil Steril. Jul 2008;90(1):1-13.
  17. Siterman S, Eltes F, Wolfson V, Zabludovsky N, Bartoov B. Effect of acupuncture on sperm parameters of males suffering from subfertility related to low sperm quality. Archives of andrology. Sep-Oct 1997;39(2):155-161.
  18. Pei J, Strehler E, Noss U, et al. Quantitative evaluation of spermatozoa ultrastructure after acupuncture treatment for idiopathic male infertility. Fertil Steril. Jul 2005;84(1):141-147.
  19. Terasawa K, Kita T, Sekiya N. Male Infertility. EBM Kampo. 2nd ed. Tokyo: Ishiyaku Publishers; 2007.
  20. Bonica JJ. Applied Anatomy Relevant to Pain. In: Bonica JJ, ed. The Management of Pain. Vol Vol. 1. 2nd ed. Pjiladelphia: Lea & Febiger; 1990:133-158.
  21. Hotta H, Uchida S, Shimura M, Suzuki H. Uterine contractility and blood flow are reflexively regulated by cutaneous afferent stimulation in anesthetized rats. Journal of the autonomic nervous system. Jan 15 1999;75(1):23-31.
  22. Sato Y, Hotta H, Nakayama H, Suzuki H. Sympathetic and parasympathetic regulation of the uterine blood flow and contraction in the rat. Journal of the autonomic nervous system. Jul 5 1996;59(3):151-158.
  23. Stener-Victorin E, Fujisawa S, Kurosawa M. Ovarian blood flow responses to electroacupuncture stimulation depend on estrous cycle and on site and frequency of stimulation in anesthetized rats. J Appl Physiol. Jul 2006;101(1):84-91.
  24. Stener-Victorin E, Kobayashi R, Kurosawa M. Ovarian blood flow responses to electro-acupuncture stimulation at different frequencies and intensities in anaesthetized rats. Auton Neurosci. Oct 31 2003;108(1-2):50-56.
  25. Stener-Victorin E, Kobayashi R, Watanabe O, Lundeberg T, Kurosawa M. Effect of electro-acupuncture stimulation of different frequencies and intensities on ovarian blood flow in anaesthetized rats with steroid-induced polycystic ovaries. Reprod Biol Endocrinol. Mar 26 2004;2:16.
  26. Uchida S, Hotta H, Kagitani F, Aikawa Y. Ovarian blood flow is reflexively regulated by mechanical afferent stimulation of a hindlimb in nonpregnant anesthetized rats. Auton Neurosci. Jul 31 2003;106(2):91-97.
  27. Uchida S, Kagitani F, Hotta H, Hanada T, Aikawa Y. Cutaneous Mechanical Stimulation Regulates Ovarian Blood Flow via Activation of Spinal and Supraspinal Reflex Pathways in Anesthetized Rats. The Japanese journal of physiology. Oct 2005;55(5):265-277.
  28. Nishijo K, Mori H, Tsukayama H, Yamashita H. Scientific Approach for Acupuncture. Journal of the Japan Society of Acupuncture and Moxibustion. 1995;45(3):177-191.
  29. Tanaka TH. The Possibilities for Optimizing Acupuncture Treatment Results through Synchronization with Somatic State: Examination of Autonomic Response to Superficial Needling During Exhalation. American Journal of Acupuncture. 1996;24(4):233-239.
  30. Tanaka TH, Leisman G, Nishijo K. The physiological responses induced by superficial acupuncture: a comparative study of acupuncture stimulation during exhalation phase and continuous stimulation. Int J Neurosci. Jun 1997;90(1-2):45-58.
  31. Tanaka TH. Fertility Difficulties Treated By Acupuncture: Analysis of 76 Pregnancy Cases. The 20th Year Anniversary WFAS International Acupuncture Congress; 2007; Beijing, China.
  32. Magarelli PC, Cridennda DK, Cohen M. Changes in serum cortisol and prolactin associated with acupuncture during controlled ovarian hyperstimulation in women undergoing in vitro fertilization-embryo transfer treatment. Fertil Steril. Dec 2009;92(6):1870-1879.
  33. H S. Infertility and Acupuncture Treatment. . The Japanese Journal of Acupuncture and Moxibustion Therapies. 2006;65(6).
  34. Paulus WE, Zhang M, Strehler E, El-Danasouri I, Sterzik K. Influence of acupuncture on the pregnancy rate in patients who undergo assisted reproduction therapy. Fertil Steril. Apr 2002;77(4):721-724.
  35. Smith C, Coyle M, Norman RJ. Influence of acupuncture stimulation on pregnancy rates for women undergoing embryo transfer. Fertil Steril. May 2006;85(5):1352-1358.
  36. Domar AD, Meshay I, Kelliher J, Alper M, Powers RD. The impact of acupuncture on in vitro fertilization outcome. Fertil Steril. Mar 2009;91(3):723-726.
  37. Andersen D, Lossl K, Nyboe Andersen A, et al. Acupuncture on the day of embryo transfer: a randomized controlled trial of 635 patients. Reproductive biomedicine online. Sep 2010;21(3):366-372.
  38. Benson M, Elkind-Hirsch K, Theall A. Impact of acupuncture before and after embryo transfer on the outcome of in vitro fertilization cycles: A prospective single blind randomized study. Fertil Steril. 2006;86:S135.
  39. Moy I, Milad MP, Barnes R, Confino E, Kazer RR, Zhang X. Randomized controlled trial: effects of acupuncture on pregnancy rates in women undergoing in vitro fertilization. Fertil Steril. Feb 2011;95(2):583-587.
  40. Paulus WE, Zhang M, Strehler E, Seybold B, Sterzik K. Placebo-controlled trial of acupuncture effects in assisted reproductive therapy. Paper presented at: Abstract of the 19th Annual Meeting of teh ESHRE2003; Madrid, Spain.
  41. Sunkara SK, Coomarasamy A, Khalaf Y, El-Toukhy T. Acupuncture and in vitro fertilization: updated meta-analysis. Hum Reprod. Aug 2009;24(8):2047-2048.
  42. El-Toukhy T, Sunkara SK, Khairy M, Dyer R, Khalaf Y, Coomarasamy A. A systematic review and meta-analysis of acupuncture in in vitro fertilisation. BJOG : an international journal of obstetrics and gynaecology. Sep 2008;115(10):1203-1213.
  43. Manheimer E, Zhang G, Udoff L, et al. Effects of acupuncture on rates of pregnancy and live birth among women undergoing in vitro fertilisation: systematic review and meta-analysis. Bmj. Mar 8 2008;336(7643):545-549.
  44. Anderson BJ, Haimovici F, Ginsburg ES, Schust DJ, Wayne PM. In vitro fertilization and acupuncture: clinical efficacy and mechanistic basis. Alternative therapies in health and medicine. May-Jun 2007;13(3):38-48.
  45. Humaidan P, Stener-Victorin E. Pain relief during oocyte retrieval with a new short duration electro-acupuncture technique–an alternative to conventional analgesic methods. Hum Reprod. Jun 2004;19(6):1367-1372.
  46. Meng P, Wang LL, Xu B, Sun HX. [Application of acupuncture compound anesthesia in transvaginal ultrasound-guided oocyte retrieval]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. Jun 2008;28(6):451-455.
  47. Sator-Katzenschlager SM, Wolfler MM, Kozek-Langenecker SA, et al. Auricular electro-acupuncture as an additional perioperative analgesic method during oocyte aspiration in IVF treatment. Hum Reprod. Aug 2006;21(8):2114-2120.
  48. Stener-Victorin E, Waldenstrom U, Nilsson L, Wikland M, Janson PO. A prospective randomized study of electro-acupuncture versus alfentanil as anaesthesia during oocyte aspiration in in-vitro fertilization. Hum Reprod. Oct 1999;14(10):2480-2484.
  49. Zhang J, Wang X, Lu R. Analgesic effect of acupuncture at hegu (LI 4) on transvaginal oocyte retrieval with ultrasonography. J Tradit Chin Med. Jun 2013;33(3):294-297.
  50. Gejervall AL, Stener-Victorin E, Moller A, Janson PO, Werner C, Bergh C. Electro-acupuncture versus conventional analgesia: a comparison of pain levels during oocyte aspiration and patients’ experiences of well-being after surgery. Hum Reprod. Mar 2005;20(3):728-735.
  51. Norman RJ, Clark AM. Obesity and reproductive disorders: a review. Reproduction, fertility, and development. 1998;10(1):55-63.
  52. Jenkins C, Wilson R, Roberts J, Miller H, McKillop JH, Walker JJ. Antioxidants: their role in pregnancy and miscarriage. Antioxid Redox Signal. Fall 2000;2(3):623-628.
  53. Burstein E, Perumalsamy A, Bentov Y, Esfandiari N, Jurisicova A, Casper RF. Co-Enzyme supplementaion improves ocarian response and mitochondrial function in aged mice. Fertil Steril. 2009;92:S31.
  54. Bentov Y, Casper RF. The aging oocyte–can mitochondrial function be improved? Fertil Steril. Jan 2013;99(1):18-22.
  55. Safarinejad MR. Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. The Journal of urology. Jul 2009;182(1):237-248.
  56. Festa R, Giacchi E, Raimondo S, et al. Coenzyme Q10 supplementation in infertile men with low-grade varicocele: an open, uncontrolled pilot study. Andrologia. Sep 2014;46(7):805-807.
  57. Liang L. Acupuncture & IVF. First ed. Boulder, CO: Blue Poppy Press; 2003.
  58. Terasawa K, Kita T, Sekiya N. Gynecology. EBM Kampo. 2nd ed. Tokyo: Ishiyaku Publishers; 2007.
  59. Grajewski B, Nguyen MM, Whelan EA, Cole RJ, Hein MJ. Measuring and identifying large-study metrics for circadian rhythm disruption in female flight attendants. Scand J Work Environ Health. Oct 2003;29(5):337-346.
  60. Ahlborg G, Jr., Axelsson G, Bodin L. Shift work, nitrous oxide exposure and subfertility among Swedish midwives. Int J Epidemiol. Aug 1996;25(4):783-790.
  61. Bisanti L, Olsen J, Basso O, Thonneau P, Karmaus W. Shift work and subfecundity: a European multicenter study. European Study Group on Infertility and Subfecundity. J Occup Environ Med. Apr 1996;38(4):352-358.
  62. Mozurkewich EL, Luke B, Avni M, Wolf FM. Working conditions and adverse pregnancy outcome: a meta-analysis. Obstet Gynecol. Apr 2000;95(4):623-635.
  63. Nurminen T. Female noise exposure, shift work, and reproduction. J Occup Environ Med. Aug 1995;37(8):945-950.
  64. Nurminen T. Shift work and reproductive health. Scand J Work Environ Health. 1998;24 Suppl 3:28-34.
  65. Scott AJ. Shift work and health. Prim Care. Dec 2000;27(4):1057-1079.
  66. Nakamura K, Sheps S, Arck PC. Stress and reproductive failure: past notions, present insights and future directions. Journal of assisted reproduction and genetics. Feb-Mar 2008;25(2-3):47-62.
  67. Chrousos GP, Torpy DJ, Gold PW. Interactions between the hypothalamic-pituitary-adrenal axis and the female reproductive system: clinical implications. Ann Intern Med. Aug 1 1998;129(3):229-240.
  68. Matsubayashi H, Iwasaki K, Hosaka T, et al. Spontaneous conception in a 50-year old woman after giving up in-vitro-fertilization (IVF) treatments: involvement of the psychological relief in successful pregnancy. Tokai J Exp Clin Med. Apr 2003;28(1):9-15.
  69. Eugster A, Vingerhoets AJ. Psychological aspects of in vitro fertilization: a review. Soc Sci Med. Mar 1999;48(5):575-589.
  70. Gallinelli A, Roncaglia R, Matteo ML, Ciaccio I, Volpe A, Facchinetti F. Immunological changes and stress are associated with different implantation rates in patients undergoing in vitro fertilization-embryo transfer. Fertil Steril. Jul 2001;76(1):85-91.
  71. Smeenk JM, Verhaak CM, Vingerhoets AJ, et al. Stress and outcome success in IVF: the role of self-reports and endocrine variables. Hum Reprod. Jan 21 2005.
  72. Schenker JG, Meirow D, Schenker E. Stress and human reproduction. Eur J Obstet Gynecol Reprod Biol. Jun 16 1992;45(1):1-8.
  73. Sher G, Davis V, Stoess J. In Vitro Fertrilization. New York: Facts on File; 1998.
  74. Kupka MS, Dorn C, Richter O, Schmutzler A, van der Ven H, Kulczycki A. Stress relief after infertility treatment–spontaneous conception, adoption and psychological counselling. Eur J Obstet Gynecol Reprod Biol. Oct 10 2003;110(2):190-195.
  75. Harlow CR, Fahy UM, Talbot WM, Wardle PG, Hull MG. Stress and stress-related hormones during in-vitro fertilization treatment. Hum Reprod. Feb 1996;11(2):274-279.
  76. Lee YA, Hyun KJ, Tokura H. The effects of skin pressure by clothing on circadian rhythms of core temperature and salivary melatonin. Chronobiol Int. Nov 2000;17(6):783-793.
  77. Miyatsuji A, Matsumoto T, Mitarai S, Kotabe T, Takeshima T, Watanuki S. Effects of clothing pressure caused by different types of brassieres on autonomic nervous system activity evaluated by heart rate variability power spectral analysis. J Physiol Anthropol Appl Human Sci. Jan 2002;21(1):67-74.
  78. Lee YA, Kikufuji N, Tokura H. Field studies on inhibitory influence of skin pressure exerted by a body compensatory brassiere on the amount of feces. J Physiol Anthropol Appl Human Sci. Jul 2000;19(4):191-194.
  79. Takasu N, Furuoka S, Inatsugi N, Rutkowska D, Tokura H. The effects of skin pressure by clothing on whole gut transit time and amount of feces. J Physiol Anthropol Appl Human Sci. May 2000;19(3):151-156.

(Original version of this FAQs was posted on in 2002 by Tim H. Tanaka, Ph.D.)

Prev blue 200w